Novel Class of Hydrogen Sulphide Donor Molecules

Oxidative stress causes damage to cells and is linked especially to hear ailment and cancer, and also Parkinson and Alzheimer disease. According to Michael Pluth, a lecturer of chemistry and co-associate of the study, “We have introduced tiny organic molecules that can be fabricated to release a molecule known as carbonyl sulphide, which is the most popular sulphur comprising molecule in the atmosphere, but more vitally transforms instantly to hydrogen sulphide under environmental conditions.”

Hydrogen sulphide, a colourless gas, has long been known for its dangerous toxicity and its awful smell in the environment, but it is also released by mammals, comprising humans, with vital roles in molecular signalling and cardiac health.

Initially, Pluth’s doctoral colleague Andrea Steiger, head author of the ACS paper utilized benzyl thiocarbamates to prepare responsive organic molecules that release carbonyl sulphide. For the other research work, postdoctoral scientist Yu Zhao, adapted the molecule so it remains stable and nontoxic till cellular conditions augment it to release the carbonyl sulphide that is transformed to hydrogen sulphide by carbonic anhydrase enzymes in the body.

Identifying a method to generate restorative hydrogen sulphide in the body has been an aim of numerous scientist labs around the globe in the last two decades. Scientists in the Pluth’s laboratory in 2013 introduced a probe that identifies the gas in biological samples, offering a framework to test potential donor molecules, either synthetically generated or isolated from natural products.

“For doing so we need to develop novel chemistry,” says Pluth. “We are synthetic chemists. We create molecules with the aim of introducing novel scientific tools or therapeutic tools. As for rectifying the ailment, we are not there yet, but such cell-based researches suggest that such sorts of protective effects might be feasible.”

During a heart attack or blood loss, for instance, enhanced levels of reactive oxygen elements like hydrogen peroxide emerge, confirms Pluth. The very recently introduced donor molecules are programmed to react to the overexpression of reactive oxygen species. Present hydrogen sulphide donors are mainly slow-release molecules that donate hydrogen sulphide passively.

Considered together, the two studies reveal that it is feasible to construct molecular scaffolds to release carbonyl sulphide and then hydrogen sulphide by preparing a boost in the molecule to begin the process of delivery.

“One of the aims of developing such small hydrogen sulphide molecules is the potential for long-term applications in therapeutics,” says Pluth. “Having scientists nearby who emphasis on translating basic scientific discoveries into the market applications would boost further expansion of such work,” he says. The goal of UO’s Phill and Penny Knight Campus is to advance such basic study